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Abstract #2149

Early Post-Ischemic Neuroprotective Mechanisms: A MR Spectroscopic Imaging Study on PPARβ-Deficient Mice

Mlanie Craveiro1, Laure Quignodon2, Carole Berthet3, Matthew Hall2, Cristina Cudalbu1, Lorenz Hirt3, Batrice Desvergne2, Rolf Gruetter1,4

1Laboratory for Functional & Metabolic Imaging, Ecole Polytechnique Fdrale de Lausanne, Lausanne, Switzerland; 2Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland; 3Department of Neurology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; 4Departments of Radiology, Universities of Lausanne & Geneva, Switzerland

Recent studies have shown the neuroprotective role of PPARβ (peroxisome proliferator-activated receptor β) in several brain diseases and an increased sensitivity of PPARβ-knockout mice to ischemia. The aim of this study was to detect the metabolites involved in the neuroprotection through an early neurochemical comparison between PPARβ-knockout and wild-type mice after brain ischemia using MR spectroscopic imaging (SI). The use of SI on an ultra-high field 14.1 T provided a sensitive means to map the in vivo metabolite concentrations and allowed a sensitive localization of the lesion site. Finally, this study provided an optimal evaluation of metabolite concentration alterations inside the lesion caused by the neuroprotective deficit of PPARβ-knockout mice.