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Abstract #2156

In Vivo Kurtosis Imaging in Murine Cerebral Ischemia

Andreas Lemke1, Saskia Grudzenski2, Jrg Dpfert1, Frederik Bernd Laun3, Tristan Kuder3, Marc Fatar2, Lothar Rudi Schad1

1Computer Assisted Clinical Medicine, Heidelberg University, Mannheim, Germany; 2Experimental Neurology, Heidelberg University, Mannheim, Germany; 3Department of Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany

Diffusion kurtosis imaging of eight mice with induced middle cerebral artery occlusion (MCAo) was performed 24 h after MCAo using a cryo probe and a 9.4 T animal scanner. The apparent diffusion coefficient (Dapp=0.490.09 m/ms vs. 0.750.05 m/ms, P=0.0078), and the fractional anisotropy (FA=0.070.02 vs. 0.100.02, P=0.039) are significantly decreased in the ischemic tissue compared to the healthy contralateral tissue, whereas the kurtosis is significantly increased in the ipsilateral region (Kapp=1.150.10 vs. 0.660.09, P=0.0078).