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Abstract #2182

Quantitative Analysis of the Substantia Nigra in Parkinson's Disease Implementing 3D Modeling at 7.0T MRI

Hye-Jin Jeong1, Se-Hong Oh1, Jong-Min Kim2, Dae-Hyuk Kwon1, Sung-Yeon Park1, Joshua H. Park1, Young-Bo Kim1, Je-Geun Chi1,3, Chan-Woong Park1, Beom S. Jeon2, Zang-Hee Cho1

1Neuroscience Research Institute, Gachon University of Medicine & Science, Incheon, Korea, Republic of; 2Department of Neurology ,College of Medicine, Seoul National University, Seoul, Korea, Republic of; 3Departments of Pathology,College of Medicine, Seoul National University, Seoul, Korea, Republic of

Using 3D T2*-weighted images obtained with 7.0T MRI, we were able to observe definition of entire structure of the substantia nigra (SN) in Parkinsons disease (PD). Especially, change of inner structure of the SN which is believed to be the nigrosomes was shown. These findings appear in correlation analysis. The measured correlation analyses show that there is age dependent correlation and substantially UPDRS motor score dependent correlation in PD patients. These results suggest 7.0T 3D T2*-weighted MR imaging could provide quantitative estimation of the SN in PD.