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Abstract #2183

Improved Sensitivity & Specificity in the Diagnosis of Parkinson's Disease from Diffusion Kurtosis Imaging

JiunJie Wang1, WeyYil Lin2, ChinSung Lu3, Ali Tabesh4, YiHsin Weng, YauYau Wai

1ChangGung University, TaoYuan county, Taiwan, Taiwan; 2ChangGung Memorial Hospital, TaoYuan county, Taiwan, Taiwan; 3ChangGung Memorial Hospital; 4NewYork University Medical School

The mean diffusion kurtosis was measured from 30 patient of idiopathic Parkinsons Disease. Compared with diffusion tensor derived indices, such as Fractional Anisotropy and mean/axial/radial diffusivity, the mean kurtosis in the basal ganglia has significantly improved diagnostic performance in differentiating from normal controls. The receiver operative curve analysis showed the best performance in substantia nigra, which has a sensitivity and specificity of approximately 0.87 and 0.92.