Yuhei Takado1,2, Hironaka Igarashi1,
Kenshi Terajima1,2, Takayoshi Shimohata2, Masaki Okubo1,3,
Kouichirou Okamoto1,4, Masatoyo Nishizawa1,2, Tsutomu
Nakada1
1Center for Integrated
Human Brain Science, Brain Research Institute, University of Niigata,
Niigata, Japan; 2Neurology, Brain Research Institute, University
of Niigata, Niigata, Japan; 3Institute of Medicine & Dentistry
Basic Radiological Technology, School of Health Sciences, University of
Niigata, Niigata, Japan; 4Neurosurgery, Brain Research Institute,
University of Niigata, Niigata, Japan
The purpose of this study is to seek cerebral abnormalities in myotonic dystrophy type1 (DM1) using 1H-MRS at a 3.0 T scanner. We performed Single-voxel 1H-MRS (frontal white matter and frontal cortex) and MRSI. Brain metabolites were correlated with frontal assessment battery (FAB). The ratio of NAA/Cr in the frontal cortex was negatively correlated with the number of trinucleotide cytosine-thymine-guanine repeats (r = -0.67, p < 0.05). The ratio of NAA/Cr in the frontal white matter was positively correlated with FAB (r = 0.62, p < 0.05). These results probably reflect the microenvironment of the CNS impairment in DM1 patients.