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Abstract #2232

In Vivo Neuronal Transport Impairment Reflects the Level of Abnormal Tau in a Mouse Model of Tauopathy : A Track-Tracing Memri Study

Anne Bertrand1,2, Umer Khan2, Dung Minh Hoang2, Dmitry Novikov2, Pavan Krishnamurthy3, Hameetha Banu Rajamohamed Sait3, Benjamin Winthrop Little2, Einar M. Sigurdsson3, Youssef Zaim Wadghiri2

1URA CEA-CNRS 2210, MIRCen, Fontenay-Aux-Roses, France; 2Radiology, NYULMC, New York, United States; 3Physiology & Neuroscience, NYULMC, New York, United States

Our aim was to study in vivo the neuronal transport in a mouse model of tauopathy, using manganese-enhanced MRI (MEMRI). We show that 1) JNPL3[P301L] mice display a progressive impairment of neuronal transport with aging; 2) the degree of neuronal transport impairment is correlated with the level of tauopathy in neurons. Thus, MEMRI provides a useful biomarker that can be used during the pre-clinical evaluation of new drugs against Alzheimers disease.