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Abstract #2239

T2 Alterations in Ex Vivo Human Brains with Alzheimer's Disease Pathology

Robert J. Dawe1, Julie A. Schneider2, David A. Bennett2, Konstantinos Arfanakis1

1Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, United States; 2Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, United States

Postmortem MRI of the human brain allows for comparison of imaging findings with histopathologic data, providing a unique opportunity to evaluate the sensitivity of new MRI techniques to tissue changes related to Alzheimers disease (AD) and other neurodegenerative diseases. The purpose of this work was to investigate differences in T2 relaxation times among postmortem brain specimens with low, intermediate, and high likelihood of AD, assessed histopathologically, according to the National Institute on Aging (NIA)-Reagan Institute criteria. T2 elevation was detected in periventricular and subcortical white matter regions, and T2 depression was detected in the globus pallidus and putamen.