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Abstract #2244

Combined 1H MRS & Near-Infrared Spectroscopy Measurements of Cerebral Blood Volume, Oxygenation, Cytochrome Oxidase & Intracellular Metabolites During Perinatal Hypoxia-Ischaemia

Alan Bainbridge1, Ilias Tachtsidis2, Stuart Faulkner3, Sonya Mahony2, David Price1, David .L Thomas4, Ernest B. Cady1, Nicola J. Robertson3, Xavier Golay4

1Medical Physics & Bioengineering, UCLH NHS Foundation Trust, London, United Kingdom; 2Department of Medical Physics & Bioengineering, University College London, London, United Kingdom; 3Institute for Womens Health, UCL, London, United Kingdom; 4Institute of Neurology, UCL, United Kingdom

To investigate brain haemodynamic and metabolic changes during hypoxia-ischemia (HI) and recovery we integrated broadband near-infrared spectroscopy (NIRS) with proton magnetic resonance spectroscopy (MRS). Experiments were performed under UK Home Office guidelines on a healthy piglet. The NIRS optodes were integrated with a surface coil and fixed on the top of the piglets head. We measured Lactate/N-acetyl-aspartate ratio using MRS and cerebral blood volume (CBV), cerebral oxygenation and the redox state of cytochrome-c-oxidase (ox-redCCO) using NIRS. NIRS provides complementary information to 1H MRS that may improve our understanding of the response of the newborn brain to HI.