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Abstract #2245

Can 1H MRS Be a Surrogate for 31P MRS in Quantification of Transient Hypoxic-Ischemic Insult Severity in a Neonatal Encephalopathy Model?

Alan Bainbridge1, Stuart Faulkner2, Dorottya Kelen2, Manigandan Chandrasekaran2, David Price1, David L. Thomas3, Ernest B. Cady1, Nicola J. Robertson2, Xavier Golay3

1Medical Physics & Bioengineering, UCLH NHS Foundation Trust, London, United Kingdom; 2Institute for Womens Health, UCL, London, United Kingdom; 3Institute of Neurology, UCL, United Kingdom

In this study we correlated 1H MRS Lac/Naa with 31P metabolite ratios in order to assess whether 1H MRS could facilitate titration of hypoxia-ischemia (HI). Thirteen healthy piglets were studied. Transient cerebral HI was induced by reducing the inspired oxygen fraction inflating bilateral carotid artery occluders for ~ 25 min. 10 piglets were monitored with 31P MRS and the other 3 were monitored with 1H MRS during and after HI. Correlating median timecourses suggests that Lac/Naa is not a direct marker of either energy reserve or status. However, 1H MRS is potentially useful for quantifying insult severity.