In-Young Choi1,2, Wen-Tung Wang1, Joanne Marcario1, Mark Levine3, Phil Lee1,4
1Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, KS, United States; 2Department of Neurology, University of Kansas Medical Center, Kansas City, KS, United States; 3Molecular & Clinical Nutrition Section, National Institute of Health, Bethesda, MD, United States; 4Molecular & Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, United States
Ascorbate (Ascorbic acid or vitamin C), a critical antioxidant, is most concentrated in the brain. However, However, the mechanism of cellular accumulation of ascorbate in the CNS has not been clearly demonstrated. In this study, we aim to measure cerebral ascorbate levels under the high concentration gradients between blood and the brain in order to investigate whether ascorbate levels can be modulated in the brain in vivo via intraperitoneal (i.p.) infusion using ultra-short echo time 1H MRS at 9.4 T.