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Abstract #2253

In Vivo Assessment of Neuronal Metabolic Fluxes in Mouse Brain by 1H-[13C] NMR Spectroscopy

Lijing Xin1, Hongxia Lei2, Bernard Lanz2, Rolf Gruetter1,2

1Department of Radiology, University of Lausanne, Lausanne, Vaud, Switzerland; 2Laboratory of functional & metabolic imaging, cole Polytechnique Fdrale de Lausanne, Lausanne, Vaud, Switzerland

<sup>13C MRS combined with the administration of 13C labeled substrates for transgenic mouse models will provide insights into the metabolism in brain pathologies. In the present study, separated 13C labeling turnover curves of GluC4, GlnC4, GlxC3 and LacC3 were obtained in mouse brain in vivo at 14T by 1H-[13C] MRS, which allows us to determine metabolic fluxes without additional blood sampling. This study can be extended to transgenic mouse models for further investigation of brain pathologies.