Andreas Deistung1, Jan Klohs2, Ferdinand Schweser1, Joanes Grandjean2, Marco Dominietto2, Conny Waschkies2, Roger M. Nitsch3, Markus Rudin2,4, Jrgen R. Reichenbach5
1Medical Physics Group, Department of Diagnostic & Interventional Radiology I, Jena University Hospital , Jena, Germany; 2Institute for Biomedical Engineering, ETH & University of Zrich, Switzerland; 3Division of Psychiatry Research, University of Zrich, Switzerland; 4Institute of Pharmacology & Toxicology, University of Zrich , Switzerland; 5Medical Physics Group, Department of Diagnostic & Interventional Radiology I, Jena University Hospital, Jena, Germany
This study aims at optimizing quantitative susceptibility mapping (QSM) for high resolution MR imaging of mice brains and evaluating its potential to characterize the punctuate lesions in the brain of arcAβ mice. Furthermore, the regional differences of the brain tissue iron load are investigated in both living transgenic arcAβ (n=3) mouse and wild type (n=6) controls. VOI-based analysis of cortical, hippocampal, thalamic and white matter tissue revealed no significant differences in magnetic susceptibilities between brain regions in arcAβ compared to wt mice. However, a tendency of regional variances of magnetic susceptibility values in lesions was found.