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Abstract #2274

Voxel-Based Morphometry Reveals Localised Cerebral Atrophy in a Mouse Lemur Model of Aging

Stephen John Sawiak1,2, Marc Dhenain3

1Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, England, United Kingdom; 2Behavioural & Clinical Neurosciences Institute, University of Cambridge, Cambridge, United Kingdom; 3MIRCen, I2BM Institute of Biomedical Imaging, Fontenay aux Roses, France

Voxel-based morphometry is applied to 30 mouse lemur brains of ages 2-11 years and shows localised changes with age, of particular note cingulate and entorhinal cortical reductions in grey matter concentrations are seen. This shows that automated techniques can be applied in this area leading to greater sensitivity with less manual bias.