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Abstract #2284

Early Metabolic Changes in the Amyotrophic Lateral Sclerosis SOD1 Mouse Brain Are Revealed using 1H MRS Rather Than CASL & 18FDG PET

Hongxia Lei1,2, Elisabeth Dirren3, Carol Poitry-Yamate1, Bernard L. Schneider3, Patrick Aebischer3, Rolf Gruetter1,4

1Laboratory of Functional & Metabolic Imaging, Ecole Polytechnique Fdrale de Lausanne, Lausanne, Switzerland; 2Radiology, Univeristy of Lausanne, Lausanne, Switzerland; 3Brain Mind Institute, Ecole Polytechnique Fdrale de Lausanne, Lausanne, Switzerland; 4Radiology, University of Geneva, Geneva, Switzerland


Multimodal and non-invasive studies of SOD1 mouse brain allow following metabolic changes longitudinally in G93A SOD1 mice, an animal model mimicking human ALS. Metabolic changes are observed at two different time-points -- before and after apparition of the symptoms -- suggesting that 1H MRS is an effective strategy towards identifying potential biomarkers of ALS during the early post-symptomatic phase.