Abstract #2284

Early Metabolic Changes in the Amyotrophic Lateral Sclerosis SOD1 Mouse Brain Are Revealed using 1H MRS Rather Than CASL & 18FDG PET

Hongxia Lei^1,2, Elisabeth Dirren³, Carol Poitry-Yamate¹, Bernard L. Schneider³, Patrick Aebischer³, Rolf Gruetter^1,4

¹Laboratory of Functional & Metabolic Imaging, Ecole Polytechnique Fdrale de Lausanne, Lausanne, Switzerland; ²Radiology, Univeristy of Lausanne, Lausanne, Switzerland; ³Brain Mind Institute, Ecole Polytechnique Fdrale de Lausanne, Lausanne, Switzerland; ⁴Radiology, University of Geneva, Geneva, Switzerland

Multimodal and non-invasive studies of SOD1 mouse brain allow following metabolic changes longitudinally in G93A SOD1 mice, an animal model mimicking human ALS. Metabolic changes are observed at two different time-points -- before and after apparition of the symptoms -- suggesting that 1H MRS is an effective strategy towards identifying potential biomarkers of ALS during the early post-symptomatic phase.