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Abstract #2288

Longitudinal Study of Neurochemical Changes in Q140 Mouse Model of Huntingtons Disease

Ivan Tkac1, Lori Zacharoff2, Janet M. Dubinsky2

1Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States; 2Department of Neuroscience, University of Minnesota

In vivo 1H NMR spectroscopy at 9.4T was used to investigate the neurochemical changes in the striatum and cerebral cortex of the Q140 knock-in mouse model of Huntingtons disease (HD). Mice were scanned repeatedly during the their lifespan (6 weeks 24 months). More than 300 spectra were acquired. Most significant changes were observed for Gln, PCr, PE and Lac and were mostly localized in mouse striatum, which more closely mimic symptoms found in HD human patients.