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Abstract #2308

In-Vivo Mouse Brain DT-MRI: Assessment of Gender Specific Response to the Thyroid Hormone Remyelinating Treatment

Laura-Adela Harsan1, Alexandru Parlog1, Neele Hbner1, Jrgen Hennig1, Dominik von Elverfeldt1

1Department of Radiology, Medical Physics, University Hospital Center, Freiburg, Germany

In the present study we comparatively investigated by quantitative DT-MRI, the response of the cuprizone demyelinated male and female mice to a remyelinating therapy based on thyroid hormones. Increased radial diffusivity in the white matter of cuprizone mice was associated with myelin loss and axonal injury. Three weeks of daily injections with T3, gradually restored the myelin layers and induced recovery in both genders. A certain trend of faster and more consistent remyelination was observed in the female mice. The results are valuable for understanding the role of gender in the physiopathology and regeneration of the brain white matter.