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Abstract #2309

Correlation between DTI & Visual Evoked Potential in Mice with Optic Neuritis

Dan Xu1, Hsiao-Fang Liang2, Wei-Xing Shi, Shu-Wei Sun3

1Pharmaceutical Sciences & Basic Sciences, Schools of Pharmacy & Medicine, Loma Linda University, Loma Linda, CA, United States; 2Biophysics & Bioengineering, Loma Linda University; 3Biophysics & Bioengineering, Loma Linda University, Loma Linda, CA, United States

Diffusion tensor imaging (DTI) and visual evoked potential (VEP) recording were performed in mice with chronic experimental autoimmune encephalomyelitis (EAE), an animal model of optic neuritis. Correlation analysis showed that VEP amplitudes were significantly correlated with DTI indices of the optic nerves and optic tracts, providing the evidence that microstructural changes detected by DTI are associated with functional alteration.