Abstract #2309

Correlation between DTI & Visual Evoked Potential in Mice with Optic Neuritis

Dan Xu¹, Hsiao-Fang Liang², Wei-Xing Shi, Shu-Wei Sun³

¹Pharmaceutical Sciences & Basic Sciences, Schools of Pharmacy & Medicine, Loma Linda University, Loma Linda, CA, United States; ²Biophysics & Bioengineering, Loma Linda University; ³Biophysics & Bioengineering, Loma Linda University, Loma Linda, CA, United States

Diffusion tensor imaging (DTI) and visual evoked potential (VEP) recording were performed in mice with chronic experimental autoimmune encephalomyelitis (EAE), an animal model of optic neuritis. Correlation analysis showed that VEP amplitudes were significantly correlated with DTI indices of the optic nerves and optic tracts, providing the evidence that microstructural changes detected by DTI are associated with functional alteration.