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Abstract #2325

Diffusion Tensor Metrics Changes in the White Matter of Systemic Lupus Erythematosus Patients

Maria Luisa Mandelli1, Monica Bucci1, Eduardo Caverzasi1, Mehul Sampat1, Grace Yoon2, Patricia P. Katz2, Laura Julian2, Roland G. Henry1

1Department of Radiology & Biomedical Imaging, UCSF, San Francisco, CA, United States; 2Department of Medicine, UCSF, San Francisco, CA, United States

Systemic Lupus Erythematosus is an autoimmune disorder affecting the central (CNS) nervous system often occurring in the subcortical white matter. Diffusion Magnetic Resonance Imaging is an imaging tool of choice to detect subcortical white matter damage. The purpose of this study is to investigate whether Mean Diffusivity (MD), Fractional Anisotropy (FA), and eigenvalues in the white matter of the brain of Systemic Lupus Erythematosus (SLE) patients differ from those of healthy controls. SLE patients showed a significant decrease on FA (P=0.010) and on Axial Diffusivity (λ1) (P=0.017) measures compared to control subjects in the normal appearing white matter.