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Abstract #2324

Structural Plasticity in Stroke Inferred by Probabilistic Tractography & MEG

Monica Bucci1, Kelly Westlake1, Christopher Nguyen1, Bagrat Amirbekian1, Srikantan Nagarajan1, Roland G. Henry1

1Department of Radiology & Biomedical Imaging, UCSF, San Francisco, CA, United States

Structural remodeling of white matter may occur in motor recovery after stroke. We mapped the structural connectivity of the network of hand motor function, by combining magneto-encephalography, with HARDI diffusion MRI, in 4 controls and 4 stroke subjects before and after a robotic rehabilitation intervention. In 4 control subjects we successfully mapped the structural connectivity of the motor network. When tracking in stroke patients we observed improved structural connectivity for the ipsilesional M1 connections to contralateral M1 and to the ipsilesional ventral PMC in the patient with the best recovery score and different degrees of structural changes in the others.