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Abstract #2330

Anatomical Organization of the Blind's Brain: Combined VBM & DTI Analysis

Zhi Wang1, William FC Baar2,3, Ron Kupers2, Tim Dyrby2, Olaf Paulson2, Min Chen1, Cheng Zhou1, Maurice Ptito2

1Radiology, Beijing Hospital, Beijing, China, People's Republic of; 2Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital, Hvidovre, Denmark; 3Center for Integrated Molecular Brain Imaging , Copenhagen, Denmark

We extended further our previous results by exploring here the whole brain white matter organization in a large cohort of congenital blindness(CB) compared to normal sight controls(NS) by combining VBM-DARTEL and DTI. All components of the visual system were reduced, especially the bilateral superior colliculi. All structures belonging to the visual system showed significant reductions of anatomical connectivity. Eleven of thirteen NS showed the entire visual-related fiber tracts. On the contrary, only 2 of 13 CB demonstrated the similar fiber tracts.