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Abstract #2331

White Matter Network Abnormalities Are Associated with Cognitive Decline in Chronic Epilepsy

Maarten Vaessen1,2, Jacobus Jansen1,2, Marielle Vlooswijk3, Paul Hofman1,2, Marian Majoie3,4, Albert Aldenkamp2,4, Walter Backes1,2

1Radiology, Maastricht University Medical Centre, Maastricht, Netherlands; 2School for Mental Health & Neurosciences, Maastricht University, Maastricht, Netherlands; 3Neurology, Maastricht University Medical Centre, Maastricht, Netherlands; 4Epilepsy Centre Kempenhaeghe, Heeze, Netherlands

The relation between white matter connectivity abnormalities and cognitive decline in chronic epilepsy was investigated using graph theoretical network analysis on tractography derived volumetric structural network. Clustering and path lengths appeared abnormal in epilepsy patients with cognitive impairment and were strongly correlated with IQ and IQ discrepancy scores. These results suggest that epilepsy interferes with structural networks that play a role in cognitive impairment.