Abstract #2336

Traumatic Brain Injury: Abnormal Fractional Anisotropy in the Corpus Callosum & Its Association with Injury Severity.

Cheuk Ying Tang^1,2, Emily Lauren Eaves¹, Kristen Dams-O'Connor³, Lap Ho⁴, David Carpenter¹, Johnny Ng¹, Wayne Gordon³, Giulio M. Pasinetti^4,5

¹Radiology, Mount Sinai School of Medicine, New York, United States; ²Psychiatry, Mount Sinai School of Medicine, New York, United States; ³Rehabilitation Medicine, Mount Sinai School of Medicine, New York, United States; ⁴Neurology, Mount Sinai School of Medicine, New York, United States; ⁵Psychiatry, Mount Sinai School of Medicine, New York , United States

Atrophy of the corpus callosum (CC) observed after traumatic brain injury (TBI) was assessed using diffusion tensor imaging. Prior to scanning, subjects completed a series of questionnaires to assess their emotional and cognitive functioning. A single severity score was ascertained for each TBI subject. TBI subjects reported lower emotional and cognitive scores and had lower fractional anisotropy (FA) in the CC compared to controls. The severity score negatively correlated with CC FA in the TBI group. This study indicates atrophy of the CC following TBI is due to demyelination and FA may be useful as a biological marker for TBI.