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Abstract #2337

A Diffusion Spectrum Imaging Study on Mirror Neuron System in Schizophrenia

Chieh-En Jane Tseng1, Wei-An Wang1, Yu-Chun Arica Lo2, Yi-Huan Markus Wu3, Chih-Min Liu4, Hai-Gwo Hwu4, Wen-Yih Isaac Tseng3,5

1Biomedical Imaging & Radiological Sciences, National Yang-Ming University, Taipei, Taiwan; 2Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan; 3Center for Optoelectronic Biomedicine, National Taiwan University College of Medicine, Taipei, Taiwan; 4Department of Psychiatry, National Taiwan University Hospital, Taipei, Taiwan; 5Department of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan

The mirror neuron system (MNS) has been hypothesized to be important in imitation and social cognition. Recent fMRI studies have reported MNS deficits in schizophrenia. The purpose of this study is to evaluate the white matter structure between the two areas in which mirror neurons have been identified, namely inferior frontal gyrus and inferior parietal lobule. As compared with the neurotypicals, patients showed no significant difference in generalized fractional anisotropy (GFA) bilaterally. In patients, however, positive correlations were found between the scores of social withdrawal and the GFA bilaterally.