Patricia E. Litkowski1, Victor Liu1, Kyung Peck2, Zhigang Zhang3, Kathryn Beal4, Robert J. Young1
Malignant gliomas are highly invasive tumors with poor clinical outcomes. Current treatment includes uniform radiation around the tumor region. Diffusion tensor imaging (DTI) is a promising modality that may more effectively inform radiation planning, particularly for local tumor growth. We used DTI to construct probabilistic maps based on seed ROI surrounding the tumors. The high-risk areas determined in our analysis showed a strong correlation with the locations of tumor progression, suggesting that DTI may be useful in planning targeted radiation therapy.