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Abstract #2346

Abnormal White Matter Integrity in Adolescent Students with Internet Addiction Disorder Revealed by Tract-Based Spatial Statistics

Fuchun Lin1, Yan Zhou2, Yasong Du3, Lindi Qin2, Zhimin Zhao3, Jianrong Xu2, Hao Lei1

1State Key Laboratory of Magnetic Resonance & Atomic and Molecular Physics, Wuhan Institute of Physics & Mathematics, Chinese Academy of Sciences, Wuhan, Hubei, China, People's Republic of; 2Department of Radiology, RenJi Hospital, Jiao Tong University Medical School, Shanghai, China, People's Republic of; 3Department of Child & Adolescent Psychiatry, Shanghai Mental Health Center, Jiao Tong University, Shanghai, China, People's Republic of

Tract-based spatial statistics was used to investigate white matter (WM) integrity in adolescent students with Internet addiction disorder (IAD). Compared to healthy subjects, IAD adolescent students show has abnormalities in many white matter regions including the orbital frontal, superior temporal WM, together with several commissural, association, and projection fibers. Moreover, FAs in the left genu of corpus callosum and the left anterior corona radiation were negatively correlated with behavioral features. Our findings suggested that IAD has some common neurobiological mechanisms with substance addictions and diffusion tensor imaging might be valuable in providing data on neurological prognosis for IAD.