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Abstract #2371

Visualization of the Orientational Structure of the Human Stria of Gennari with High-Resolution DWI

Christoph Wolfram Ulrich Leuze1, Bibek Dhital1, Alfred Anwander1, Andre Pampel1, Robin Heidemann1, Stefan Geyer1, Marcel Gratz2, Robert Turner1

1Max Planck Institute for Human Cognitive & Brain Sciences, Leipzig, Sachsen, Germany; 2Universitt Leipzig, Leipzig, Sachsen, Germany

Diffusion-weighted imaging (DWI) at high spatial and angular resolution was performed at 9.4T on a block of fixed human cadaver brain tissue containing visual cortex. Analysis of the principal eigenvector orientations allowed visualization of several layers within the primary visual cortex V1. No clearly preferred diffusion direction could be measured inside the stria of Gennari (SoG), consistent with its high content of transverse myelinated intracortical axons. In surrounding layers the orientational structure was predominantly radial. The low orientational anisotropy of the SoG terminates at the V1/V2 boundary, allowing easy visualization of this boundary using diffusion data alone.