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Abstract #2372

Post Mortem Quantitative MRI of the Human Brain in Situ using High-Resolution Multi-Echo FLASH

Gunther Helms1, Walter J. Schulz-Schaeffer2, Arne Wrede2, Niels K. Focke3, Peter Dechent1

1MR-Research in Neurology & Psychiatry, Universitymedicine Gttingen, Gttingen, Germany; 2Neuropathology, Universitymedicine Gttingen, Gttingen, Germany; 3Clinical Neurophysiology, Universitymedicine Gttingen, Gttingen, Germany

For post mortem MRI of the human head at 3T, a quantitative FLASH-based protocol was established yielding parameter maps of T1, R2*=1/T2*, magnetization transfer (MT) and signal amplitude at 0.65mm isotropic resolution in about 2 hours. Major post mortem changes were rapid T2*-relaxation in vessels and progressive loss of T1-contrast at low temperature, hampering standard T1w MRI. At room temperature, MT saturation maps showed a high unchanged contrast in brain independent of altered T1 and T2*, while the MT ratio was reduced. In cooled brains, the MT contrast was slightly reduced and R2* was enhanced in the deep brain nuclei.