Abstract #2400

In Vivo Detection of Glial Activity After Transient Forebrain Ischemia using Manganese-Enhanced MRI

Yuko Kawai¹, Yuko Yasuda², Narito Tateishi², Masahiro Umeda¹, Yasuharu Watanabe¹, Toshihiro Higuchi³, Seiichi Furuya⁴, Shoji Naruse^2,5, Setsuya Fujita², Chuzo Tanaka³

¹Medical Informatics, Meiji University of Integrative Medicine, Kyoto, Japan; ²Basic Research, Louis Pasteur Center for Medical Research, Kyoto, Japan; ³Neurosurgery, Meiji University of integrative Medicine, Kyoto, Japan; ⁴Radiology, Japanese Red Cross Kyoto Daiichi Hospita, Kyoto, Japan; ⁵Radiology, Kyoto Prefectural University of Medicine, Kyoto, Japan

The four-vessel occlusion (4-VO) is famous as forebrain ischemia model that cause delayed neuronal cell death in the CA1 region of the rat hippocampus. Recently, the glial response to CNS injury is considered in the context of neuron-glial relationships. Manganese-enhanced MRI (MEMRI) is taken notice as useful molecular imaging technique for nervous system. In this study, signal enhancement upon the Manganese accumulation was observed in the CA1 region after 4-VO by the MEMRI. MEMRI will detect glial activity which related with about of the neural death. In addition this studies suggest that astrocytic change can precede neuronal death.