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Abstract #2401

Dose Dependence of T1 & Phase Contrast Following Mn2+ Systemic Administration at 14.1T

Rajika Maddage1, Jos Pedro Marques2,3, Rolf Gruetter2,4

1Laboratory for Functional & Metabolic Imaging , Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland; 2Laboratory for Functional & Metabolic Imaging, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland; 3Department of Radiology, University of Lausanne, Lausanne, Switzerland; 4Department of Radiology, University of Lausanne & Geneva, Switzerland

At high magnetic field, phase imaging has proven to be a potential tool to trace Mn2+ enrichment in MEMRI. The aim of the study was to investigate the contrast enhancement as a function of Mn2+ dose to assess the sensitivity of T1-W and phase imaging at 14.1T. Results show that at the lowest dose of 75mg/kg, the contrast observed in the phase image remains strong with clear depiction of various anatomical structures further supporting the notion of phase imaging's high sensitivity to magnetic susceptibilities and more importantly [Mn2+].