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Abstract #2402

Dynamic Properties of Manganese-Alginate Gels for Controlled-Release of Mn2+

ystein Olsen1, Yanna Sandvig2, Yrr Mrch3, Marte Thuen2, Christian Brekken2

1Department of Technology, Sr-Trndelag University College, Trondheim, Norway; 2Department of Circulation & Medical Imaging, Norwegian University of Science & Technology, Trondheim, Norway; 3Department of Biotechnology, Norwegian University of Science & Technology, Trondheim, Norway

Manganese-enhanced MRI (MEMRI) is a versatile technique for imaging of the central nervous system. However, high concentration of manganese (Mn2+) is neurotoxic but could be managed with slow release of Mn2+ e.g. alginate gel beads. In this study we have demonstrated that the release rate of Mn2+ from alginate gel beads can be controlled by adjusting the type of alginate and different combinations of divalent ions. Furthermore, simulation show that use of Mn2+ alginate gel may reduce the maximum Mn2+ concentration by ~85% in the vitreous body