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Abstract #2442

Probing the Radiation-Induced Changes of Extravascular Extracellular Space of Parotid Glands using DCE & DW MRI

Cheng-Chieh Cheng1, Chun-Jung Juan2, Hsiao-Wen Chung1, Yee-Min Jen3, Hing-Chiu Chang1,4, Su-Chin Chiu1, Cheng-Yu Chen2, Chun-Jen Hsueh2, Yaoh-Shiang Lin5, Guo-Shu Huang2

1Graduate Institute of Biomedical Electronics & Bioinformatics, National Taiwan University, Taipei, Taiwan; 2Department of Radiology, Tri-Service General Hospital, Taipei, Taiwan; 3Department of Radiation Oncology, Tri-Service General Hospital, Taipei, Taiwan; 4Applied Science Laboratory, GE Healthcare, Taipei, Taiwan; 5Department of Otorhinolaryngology-Head & Neck Surgery, Tri-Service General Hospital, Taipei, Taiwan

Dynamic contrast-enhanced (DCE) MRI and diffusion-weighted (DW) MRI are common techniques adopted for clinical diagnoses, and were utilized in investigations of irradiated parotid glands. To the best of our knowledge, the relationship between parotid perfusion and diffusion properties has not been investigated yet. In this study, we attempted to disclose the connection of parotid gland perfusion and diffusion characteristics, before and after radiation therapy. Our results suggest that the extravascular extracellular space plays a major role in the ADC measurements.