Abstract #2442

Probing the Radiation-Induced Changes of Extravascular Extracellular Space of Parotid Glands using DCE & DW MRI

Cheng-Chieh Cheng¹, Chun-Jung Juan², Hsiao-Wen Chung¹, Yee-Min Jen³, Hing-Chiu Chang^1,4, Su-Chin Chiu¹, Cheng-Yu Chen², Chun-Jen Hsueh², Yaoh-Shiang Lin⁵, Guo-Shu Huang²

¹Graduate Institute of Biomedical Electronics & Bioinformatics, National Taiwan University, Taipei, Taiwan; ²Department of Radiology, Tri-Service General Hospital, Taipei, Taiwan; ³Department of Radiation Oncology, Tri-Service General Hospital, Taipei, Taiwan; ⁴Applied Science Laboratory, GE Healthcare, Taipei, Taiwan; ⁵Department of Otorhinolaryngology-Head & Neck Surgery, Tri-Service General Hospital, Taipei, Taiwan

Dynamic contrast-enhanced (DCE) MRI and diffusion-weighted (DW) MRI are common techniques adopted for clinical diagnoses, and were utilized in investigations of irradiated parotid glands. To the best of our knowledge, the relationship between parotid perfusion and diffusion properties has not been investigated yet. In this study, we attempted to disclose the connection of parotid gland perfusion and diffusion characteristics, before and after radiation therapy. Our results suggest that the extravascular extracellular space plays a major role in the ADC measurements.