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Abstract #2492

Tract-Based Spatial Statistics Investigation of the Effects of Hypothermic Therapy for Neonatal Encephalopathy in a South Indian Neonatal Unit

David L. Price1, Suhdin Thayyil2, Sonya Mahony1, Alan Bainbridge1, Frances M. Cowan3, M. Ayer4, B. Guhan4, Neil Marlow2, S. Shankaran5, Ernest B. Cady1, Nicola J. Robertson2

1Medical Physics & Bioengineering, University College London Hospital Foundation NHS Trust, London, United Kingdom; 2Institute for Womens Health, University College London, London, United Kingdom; 3Institute of Clinical Science, Imperial College London, London, United Kingdom; 4Calicut Medical College, Kerala, India; 5School of Medicine, Wayne State University, MI, United States

Although therapeutic hypothermia (TH) improves neurological outcomes and reduces brain injury following asphyxial neonatal encephalopathy (NE) in high-income countries, its efficacy cannot be extrapolated to low and mid income countries because of different population co-morbidities. We assessed the effect of TH on brain tissue injury following NE using diffusion tensor imaging (DTI) analysed by Tract-based Spatial Statistics (TBSS) at a neonatal unit in South India. 12 infants were randomly allocated to TH and 12 to standard care. There was no significant fractional anisotropy (FA) difference between the two groups indicating a similar degree of injury to the white matter tracts.