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Abstract #2493

Longitudinal Changes in Infant Brain Metabolites at Age 6 & 13 Months using 3D High-Speed MR Spectroscopic Imaging at 3 Tesla

Chenying Yang1, Neva Corrigan2, Mindy Olson3, Dennis Shaw3,4, Stefan Posse5, Stephen Dager1

1Department of Radiology & Bioengineering, University of Washington, Seattle, WA, United States; 2Department of Radiology, University of Washington, Seattle, WA, United States; 3Seattle Children's, Seattle, WA, United States; 4Department of Radiology , University of Washington, Seattle, WA, United States; 5Department of Neurology, University of New Mexico School of Medicine, Albuquerque, NM, United States


A novel chemical imaging method, 3-D Proton Echo Planar Spectroscopic Imaging, using high spatial resolution, short echo-time and short measurement time was applied to study infants brain development longitudinally at 6 and 12 months. The preliminary findings demonstrated the feasibility of a rapid 3D MR spectroscopic imaging protocol to evaluate metabolite changes during brain development in infants, and to further apply this approach to evaluate risk factors in abnormalities of Autism.

Keywords

brainmetaboliteinfantsmonthsspectroscopicvolumecorrectiondevelopmentinfantpreliminaryquantificationspectrastudiedsubjectswaterapproximatelychemicaldatefindingsindividuallongitudinal