Chenying Yang1,
1Department of Radiology
& Bioengineering, University of Washington, Seattle, WA, United States; 2Department
of Radiology, University of Washington, Seattle, WA, United States; 3Seattle
Children's, Seattle, WA, United States; 4Department of Radiology ,
University of Washington, Seattle, WA, United States; 5Department
of Neurology, University of New Mexico School of Medicine, Albuquerque, NM,
United States
A novel chemical imaging method, 3-D Proton Echo Planar Spectroscopic Imaging, using high spatial resolution, short echo-time and short measurement time was applied to study infants brain development longitudinally at 6 and 12 months. The preliminary findings demonstrated the feasibility of a rapid 3D MR spectroscopic imaging protocol to evaluate metabolite changes during brain development in infants, and to further apply this approach to evaluate risk factors in abnormalities of Autism.