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Abstract #2517

Cerebral Blood Flow Response to Hypoglycemia in Type 1 Diabetes

Silvia Mangia1, Federico De Martino2, Nolawit Tesfaye3, Anjali Kumar3, Elizabeth Seaquist3

1CMRR - Dept. of Radiology, University of Minnesota, Minneapolis, MN, United States; 2Dept. of Cognitive Neuroscience, University of Maastricht, Maastricht, Netherlands; 3Dept. of Medicine, University of Minnesota, Minneapolis, MN, United States

Cerebral blood flow (CBF) was measured at 3T using pulsed arterial spin labeling in 7 patients with type-1 diabetes and hypoglycemia unawareness and in 7 age-matched controls, during conditions of normoglycemia and insulin-induced hypoglycemia. Results demonstrate that controls have generally lower CBF as compared to patients in normoglycemic conditions. During hypoglycemia, CBF increases in controls in several brain regions, including the thalamus, whereas this hemodynamic response is significantly reduced in patients.