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Abstract #2518

Abnormal Resting State Functional Connectivity as a Marker for Diagnosing & Predicting Recovery in Mild Traumatic Brain Injury

Guangyu Chen1, Thomas Hammeke2, Gang Chen1, Michael McCrea2, Barney Douglas Ward1, Sarah Miller3, Shi-Jiang Li1,4

1Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States; 2Department of Neurology, Medical College of Wisconsin, Milwaukee, WI, United States; 3St. Mary's Regional Medical Center, St. Mary's Regional Medical Center, Enid, OK, United States; 4Psychiatry & Behavioral Medicine, Medical College of Wisconsin, Milwaukee, WI, United States


Mild traumatic brain (mTBI) injury shows significant functional connectivity changing between several cortex regions including hippocampus, middle frontal gyrus, superior frontal gyrus et al, and several cerebellar regions. These functional connections also can be used to monitor the recovery processing in seven weeks. Some of these connections have significant correlation with memory and balance performance scores.