Prasant Chandran1, Jaymin Upadhyay1,
Stella Markosyan2, Andrew Lisowski3,
& Biochemistry, Abbott Laboratories, Abbott Park, IL, United States; 2Neuroscience
Discovery, Abbott Laboratories, Abbott Park, IL, United States; 3Cellular
& Molecular Exploratory Toxicology, Abbott Laboratories, Abbott Park, IL,
Clinical neuroimaging studies have revealed that the schizophrenic brains exhibit oligodendrocytic white matter abnormalities. However, there is a lack of preclinical in vivo imaging assays addressing this issue. In the present study, mice fed with cuprizone mixed in diet exhibit myelin breakdown which was visualized using T2-weighted anatomical and Diffusion Tensor MR Imaging techniques. This was further confirmed by histological and immunohistochemistry staining methods. However, these pathological changes were prevented in cuprizone-exposed mice co-administered with quetiapine. These results suggest that the cuprizone-exposed mouse is a potential animal model to investigate the impact of treatments on white matter abnormalities in schizophrenia.