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Abstract #2522

Intra-Orbital Distance as a Record of Social Brain Dysmorphology in Autism.

Charlton Cheung1, Kevin Yu1, Antonia Yam2, Valencia Myint3, Yan Fung Yee4, Siew Chua5,6, Grainne Mary McAlonan5,7

1Psychiatry, University of Hong Kong, Pokfulam, Hong Kong; 2Neuroscience, University of Bristol, United Kingdom; 3Psychology, University of Cardiff, United Kingdom; 4University of Harvard, United States; 5Psychiatry, University of Hong Kong, Hong Kong, Hong Kong; 6State Key Laboratory for Brain & Cognitive Sciences; 7Key State Laboratory for Brain & Cognitive Sciences

Minor Physical Anomalies (MPAs) arise during the first trimester of prenatal life and occur more frequently in autism and related neurodevelopmental disorders. We measured intra-orbital distances from T1 weighted images of children with autism aged 6 16 years and typically developing peers. We report a significant increase in intra-orbital distance in autism. Using voxel-wise linear regression analysis intra-orbital distances were found to positively correlate with the volume of inferio-temporal regions including the amygdala in the autism group only. We suggest that intra-orbital MPA may provide a fossil record of much earlier childhood brain expansion in autism.