Abstract #2524

Dynamic Response Inhibition Network in Heroin Addicts Brain: Evidence from Functional Neuroimaging with GO/Go-Nogo Task

Zheng Yang¹, Chunming Xie^2,3, Yongcong Shao¹, Liping Fu¹, Gang Chen², Wenjun Li², Joseph Goveas⁴, Guangyu Chen², Enmao Ye¹, Lin Ma⁵, Shi-Jiang Li²

¹Beijing Institute of Basic Medical Science, Beijing, China, People's Republic of; ²Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States; ³Neurology, School of Clinical Medicine, Southeast University, Nanjing, Jiangsu, China, People's Republic of; ⁴Psychiatry & Behavioral Medicine, Medical College of Wisconsin, Milwaukee, WI, United States; ⁵The PLA General Hospital, Beijing, China, People's Republic of

Reduction in the inhibitory control plays an important role in drug addiction. Recently, task-dependent neuroimaging studies have identified several brain regions involved in the response inhibition, including bilateral inferior frontal gyrus (IFG), bilateral dorsolateral prefrontal cortex (DLPFC), medial frontal cortex (MeFG), and cingulate cortex. However, little is known about the changes within the response inhibition network while performing a specific task in subjects with heroin addiction. In this study, we investigated the changes of the response inhibition network during Go/Go-nogo task in heroin addicts. We hypothesized that task-induced dynamic changes of the response inhibition network will be found in subjects with heroin addiction.