Zheng Yang1, Chunming Xie2,3, Yongcong Shao1, Liping Fu1, Gang Chen2, Wenjun Li2, Joseph Goveas4, Guangyu Chen2, Enmao Ye1, Lin Ma5, Shi-Jiang Li2
1Beijing Institute of Basic Medical Science, Beijing, China, People's Republic of; 2Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States; 3Neurology, School of Clinical Medicine, Southeast University, Nanjing, Jiangsu, China, People's Republic of; 4Psychiatry & Behavioral Medicine, Medical College of Wisconsin, Milwaukee, WI, United States; 5The PLA General Hospital, Beijing, China, People's Republic of
Reduction in the inhibitory control plays an important role in drug addiction. Recently, task-dependent neuroimaging studies have identified several brain regions involved in the response inhibition, including bilateral inferior frontal gyrus (IFG), bilateral dorsolateral prefrontal cortex (DLPFC), medial frontal cortex (MeFG), and cingulate cortex. However, little is known about the changes within the response inhibition network while performing a specific task in subjects with heroin addiction. In this study, we investigated the changes of the response inhibition network during Go/Go-nogo task in heroin addicts. We hypothesized that task-induced dynamic changes of the response inhibition network will be found in subjects with heroin addiction.