Abstract #2525

Decoupling of Intrinsic Insula Subregional Connectivity was Associated with Episodic Memory Decline in Amnestic Mild Cognitive Impairment

Chunming Xie^1,2, Feng Bai^1,3, Xiaobin Zhang¹, Hui Yu¹, Yongmei Shi³, Yonggui Yuan⁴, Alexander Cohen², Joseph Goveas⁵, Gang Chen², Wenjun Li², Guangyu Chen², Zheng Yang⁶, Zhijun Zhang^3,4, Shi-Jiang Li²

¹Neurology, School of Clinical Medicine, Southeast University, Nanjing, Jiangsu, China, People's Republic of; ²Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States; ³Neurology, Affiliated Zhongda Hospital of Southeast University, Nanjing, Jiangsu, China, People's Republic of; ⁴Institute of Neuropsychiatry of Southeast University, Nanjing, Jiangsu, China, People's Republic of; ⁵Psychiatry & Behavioral Medicine, Medical College of Wisconsin, Milwaukee, WI, United States; ⁶Beijing Institute of Basic Medical Science, Beijing, China, People's Republic of

Neuroimaging techniques have been widely employed to study the potential neural mechanisms underlying amnestic mild cognitive impairment (aMCI) and identify the abnormalities of intrinsic connectivity networks in aMCI patients (1-3). However, little is known about the potential contribution of the insula subregional networks (ISNs) to cognitive performance in aMCI patients. The purpose of this study was to characterize the contribution of ISNs to cognitive performance in aMCI patients.