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Abstract #2526

In Vivo MRI Detection of HDAC5 During Chronic Amphetamine Stimuli

Christina H. Liu1, Jinsheng Yang1, Jia Q. Ren1, Charng-Ming Liu1, Huifang Wang1, Philip K. Liu1

1Radiology, Massachusetts General Hospital, Charlestown, MA, United States

Our research examines the mechanisms of adaptive memory in the effect of amphetamine the drug that may have been used in attention-deficit hyperactivity disorder, traumatic brain injury, narcolepsy, postural orthostatic tachycardia syndrome and chronic fatigue syndrome, and was used to diminish appetite. We have developed targeting MRI technology to view gene activities in live animal brains using micro DNA labelled- contrast agents. This technology has potential as a research tool to enable discovery of surrogate biomarkers to diagnose, target, and correlate the experimental therapies in the central nervous systems and in organs of other systems.