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Abstract #2527

Multimodal Assessment of Medial Temporal Lobe Function in Schizophrenia

Laura M. Rowland1, Elena A. Spieker1, Kimberly Kontson1, Kathryn W. Buchanan1, Peter B. Barker2, Henry H. Holcomb1,3

1Psychiatry, MPRC, University of Maryland School of Medicine, Baltimore, MD, United States; 2Russell H. Morgan Department of Radiology & Radiological Sciences, Johns Hopkins University School of Medicine; 3Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, United States

This study examined the relationship between medial temporal lobe (MTL) biochemistry measured with proton magnetic resonance spectroscopy (1H-MRS), MTL activation measured with functional magnetic resonance imaging (fMRI), and the integrity of the major white matter tract from the hippocampus measured with diffusion tensor imaging (DTI) tractography in healthy and schizophrenia subjects. MTL multimodal measures predicted healthy and schizophrenia subject group membership. Subjects with schizophrenia displayed altered MTL activation, elevated hippocampal glutamate, and compromised fornix integrity. Results also provide evidence that relational learning relies on the MTL in healthy but not schizophrenia subjects