Abstract #2578

Investigating the Role of Choroid Plexus in CSF Pulsation by Combining In-Vivo & Post-Mortem MRI

Simone Bottan¹, Andri Fritz¹, Vartan Kurtcuoglu¹, Marianne Schmid Daners², Verena Knobloch³, Christian Langkammer^4,5, Nikolaus Krebs⁵, Monika Gloor⁶, Eva Scheurer⁵, Klaus Scheffler⁴, Stefan Ropele⁴, Peter Boesiger³, Dimos Poulikakos¹, Michaela Soellinger⁴

¹Laboratory of Thermodynamics in Emerging Technologies, Department of Mechanical & Process Engineering, ETH Zurich, Zurich, Switzerland; ²Institute for Dynamic Systems & Control, ETH Zurich, Zurich, Switzerland; ³Institute for Biomedical Engineering, University & ETH Zurich, Zurich, Switzerland; ⁴Department of Neurology, Medical University of Graz, Graz, Austria; ⁵Ludwig Boltzmann Institute for Clinical-Forensic Imaging, Graz, Austria; ⁶Department of Radiology, University Hospital Basel, Basel, Switzerland

Cerebrospinal fluid (CSF) shows pulsating dynamics, due to the transmission of the cardiac pulse pressure wave to the ventricular system. The exact description of this transmission is still debated in the scientific community. Several studies have shown choroid plexus (CP) to play an important role to establish CSF dynamics. In the presented study, we evaluated volumes of CP by post-mortem bSSFP MRI and compared them to in-vivo CSF flow measurements. Our results showed a very small volumetric deformation of CP to be necessary to induce in-vivo CSF strokes in the cerebral aqueduct.