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Abstract #2578

Investigating the Role of Choroid Plexus in CSF Pulsation by Combining In-Vivo & Post-Mortem MRI

Simone Bottan1, Andri Fritz1, Vartan Kurtcuoglu1, Marianne Schmid Daners2, Verena Knobloch3, Christian Langkammer4,5, Nikolaus Krebs5, Monika Gloor6, Eva Scheurer5, Klaus Scheffler4, Stefan Ropele4, Peter Boesiger3, Dimos Poulikakos1, Michaela Soellinger4

1Laboratory of Thermodynamics in Emerging Technologies, Department of Mechanical & Process Engineering, ETH Zurich, Zurich, Switzerland; 2Institute for Dynamic Systems & Control, ETH Zurich, Zurich, Switzerland; 3Institute for Biomedical Engineering, University & ETH Zurich, Zurich, Switzerland; 4Department of Neurology, Medical University of Graz, Graz, Austria; 5Ludwig Boltzmann Institute for Clinical-Forensic Imaging, Graz, Austria; 6Department of Radiology, University Hospital Basel, Basel, Switzerland

Cerebrospinal fluid (CSF) shows pulsating dynamics, due to the transmission of the cardiac pulse pressure wave to the ventricular system. The exact description of this transmission is still debated in the scientific community. Several studies have shown choroid plexus (CP) to play an important role to establish CSF dynamics. In the presented study, we evaluated volumes of CP by post-mortem bSSFP MRI and compared them to in-vivo CSF flow measurements. Our results showed a very small volumetric deformation of CP to be necessary to induce in-vivo CSF strokes in the cerebral aqueduct.