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Abstract #2651

Evaluation of Neonatal Pathology using T1 Weighted Techniques, Snapir & Gradient Echo

Amy Kathleen McGuinness1, Christina Malamateniou1, Joanna M. Allsop1, Serena J. Counsell1, Rita G. Nunes1, Zhi Q. Wu1, Nora Tusor2, Ash Ederies2, Jo V. Hajnal1, Mary A. Rutherford1

1 Imaging Sciences Department, MRC Clinical Sciences Centre, Hammersmith Hospital, Imperial College London, London, United Kingdom; 2Neonatal Imaging Group, Hammersmith Hospital, Imperial College London, London, United Kingdom

SNAPIR, an optimized single-shot T1-weighted acquisition, improves normal brain anatomy delineation in cases of fetal motion compared to a standard T1-weighted gradient echo (T1W-GE) protocol. However, the role of SNAPIR in neonatal imaging where motion may also be an issue has not yet been established. The aim of this study was to evaluate and compare neonatal brain pathology delineation using SNAPIR and a standard T1W-GE protocol, the MP-RAGE. In the absence of motion MP-RAGE is the preferred sequence. However, SNAPIR is almost as sensitive in many pathologies and is a robust technique when motion degrades T1W GE protocols.