Thomas Christen1, Greg Zaharchuk1, Nicolas Pannetier2,3, Raphael Serduc2,3, Nicolas Joudiou2,3, Jean Claude Vial2,3, Chantal Remy2,3, Emmanuel L. Barbier2,3
1Department of Radiology, Stanford University, Stanford, CA, United States; 2U836, INSERM, Grenoble, France; 3Grenoble Institut des Neurosciences, Grenoble, France
Using numerical simulations, we analyzed the influence of assumptions of a mathematical model on estimates of T2*, blood volume fraction (BVf) and blood oxygen saturation (StO2). Our results suggest that the static dephasing regime (water diffusion neglected) is a good approximation as long as vessel radii are above 3 m and StO2 is below 80% at 3T. MR estimates of StO2 obtained using the total BVf are in good agreement with the StO2 averaged over arterial and venous compartments. According to the results obtained using microscopy data as microvascular geometry input, using straight cylinders to model blood vessels seems appropriate.