Abstract #2726

Evaluation of a New Quantitative BOLD Approach to Map Local Blood Oxygen Saturation in Healthy Rat

Pierre Bouzat^1,2, Thomas Christen^1,3, Sbastien Thomas^1,2, Nicolas Pannetier^1,4, Chantal Rmy^1,4, Jean-Franois Payen^1,2, Emmanuel L. Barbier^1,4

¹U836, Inserm, Grenoble, France; ²CHU, Grenoble, France; ³Department of Radiology, Standford University, Standford, CA, United States; ⁴Grenoble Institut des Neurosciences, Universit Joseph Fourier, Grenoble, France

To improve the accuracy and the spatial resolution of SO2MR maps obtained with quantitative BOLD approaches, an approach which combines a steady-state Blood Volume fraction measurement scheme, B0 and T2 mapping techniques, and a simpler mathematical model has recently been proposed. In this study, we evaluate the proposed acquisition scheme in healthy rats (n=17) while varying the inspired oxygen fraction and using a complete physiological control. We obtained a correlation between SO2MR and oxygen saturation measured in the sagital sinus of 0.84.