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Abstract #2726

Evaluation of a New Quantitative BOLD Approach to Map Local Blood Oxygen Saturation in Healthy Rat

Pierre Bouzat1,2, Thomas Christen1,3, Sbastien Thomas1,2, Nicolas Pannetier1,4, Chantal Rmy1,4, Jean-Franois Payen1,2, Emmanuel L. Barbier1,4

1U836, Inserm, Grenoble, France; 2CHU, Grenoble, France; 3Department of Radiology, Standford University, Standford, CA, United States; 4Grenoble Institut des Neurosciences, Universit Joseph Fourier, Grenoble, France

To improve the accuracy and the spatial resolution of SO2MR maps obtained with quantitative BOLD approaches, an approach which combines a steady-state Blood Volume fraction measurement scheme, B0 and T2 mapping techniques, and a simpler mathematical model has recently been proposed. In this study, we evaluate the proposed acquisition scheme in healthy rats (n=17) while varying the inspired oxygen fraction and using a complete physiological control. We obtained a correlation between SO2MR and oxygen saturation measured in the sagital sinus of 0.84.