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Abstract #2727

Is T2* Enough to Assess Oxygenation? A Quantitative Blood-Oxygen Level Dependent Analysis in Brain Tumors.

Thomas Christen1, Benjamin Lemasson2,3, Nicolas Pannetier3,4, Regine Farion3,4, Chantal Remy3,4, Greg Zaharchuk1, Emmanuel L. Barbier3,4

1Department of radiology, Stanford University, Stanford, CA, United States; 2Departments of Radiology, University of Michigan, Center for Molecular Imaging,, Ann Arbor, MI, United States; 3Grenoble Institut des Neurosciences, Grenoble, France; 4U836, INSERM, Grenoble, France

We have analyzed how the addition of the transverse relaxation parameter (T2), the macroscopic field inhomogeneities (∆B0) and the blood volume fraction (BVf) to the estimates of magnetic resonance T2* influences the interpretation of BOLD oximetry results in a rat cerebral tumor model. We found no significant correlations between T2* and all other parameters in both tumor and healthy tissues. A lack of inclusion of any of these parameters may lead to incorrect assumptions about tumor oxygenation. Combining the parameters according to a quantitative BOLD approach leads to blood oxygenation (SO2) values independent of the initial T2* and consistent with previous measurements.