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Abstract #2773

CEST MRI of Human Liver at 3T

Kejia Cai1, Anup Singh1, Kalli Grasley1, Mohammad Haris1, Damodar Reddy1, Hari Hariharan1, Ravinder Reddy1

1CMROI, Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States

Liver is a vital organ that regulates many key metabolites in the body. A number of metabolites with chemical exchange saturation transfer (CEST) effects have been shown to change in liver diseases. However, CEST MRI of liver in-vivo is vulnerable to motion artifacts. We have implemented a CEST FLASH (Fast Low Angle SHot) imaging sequence at 3T clinical scanner, with which artifact-free CEST images can be acquired in a single breath hold. CEST Z-spectral asymmetry profile from the liver has been characterized. CEST MRI of liver may open a new way to look in to liver diseases.