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Abstract #2772

High Resolution Imaging of Myo-Insitol in Alzhemiers Disease Pathology

Mohammad Haris1, Anup Singh1, Kejia Cai1, Kavindra Nath2, Rachelle Berger1, Ari Borthakur1, Hari Hariharan1, Ravinder Reddy1

1CMROI, Radiology, University of Pennsylvania, Philadelphia, PA, United States; 2LMI, Radiology, University of Pennsylvania

The concentration of MI has been shown to change in Alzheimers disease (AD) pathology. Earlier, whole brain mapping of MI has been performed using chemical exchange saturation transfer (CEST) imaging. Here, we mapped the change in MI concentration, at high resolution, in transgenic AD mice brain (APP/PS1, n=3) using CEST technique. Compared to wild type mice (n=2), AD mice showed a significant increased MICEST contrast, which was also in good agreement with the changes in proton spectroscopy of MI. This method potentially provides a quantitative tool for measuring early molecular changes associated with the disease progression in AD.