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Abstract #2775

Keyhole Chemical Exchange Saturation Transfer

Gopal Varma1, Robert E. Lenkinski1, Elena Vinogradov1

1Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States

Contrast from chemical exchange saturation transfer (CEST) often requires multiple acquisitions. The keyhole technique is implemented that combines low-resolution data acquired at different saturation frequencies with a high-resolution reference image. CEST images reconstructed using the keyhole technique are compared with those obtained using standard acquisition at the same resolution and are shown to produce a comparable contrast for gagCEST. In particular, a keyhole image shows distinction of a cartilage sample from its surroundings that is not visible from the low-resolution data alone. Thus keyhole CEST provides a detectable contrast with significant reduction in acquisition time of the complete dataset.