Craig K Jones1,2, Daniel Polders3,
Jun Hua1, Hans Hoogduin4, He Zhu1, Jinyuan
Zhou1,2, Peter C. M. van Zijl1,2
1FM Kirby Center, Kennedy
Krieger Institute, Baltimore, MD, United States; 2Department of
Radiology & Radiological Sciences, Johns Hopkins Medical Institutes,
Baltimore, MD, United States; 3Department of Radiology, University
Medical Center Utrecht, Utrecht, Netherlands; 4Brain Division,
University Medical Center Utrecht, Utrecht, Netherlands
A 3D whole-brain pulsed CEST technique employing steady state saturation provide high resolution CEST images at 7T with limited to negligible interference of direct water or conventional magnetization transfer contrast. Amide proton transfer was calculated by fitting the acquired z-spectra to a Lorentzian, calculating the difference spectra and quantifying the mean difference between 3.2 and 3.8 ppm. Maps of the amide proton transfer was displayed from a normal volunteer.